Masters Thesis

Interaction of 2'-hydroxyacetophenone and trichloroacetic acid

Hydrogen bonding can be defined as an association of two different functional groups. One of these groups must have a proton such as the hydrogen of carboxyl, hydroxy 1 or amine group. The other group must have an electron donor atom such as oxygen in carbonyls or ethers, and nitrogen in amines. In general, there are two classes of hydrogen bonding: the hydrogen bonding occurring between molecules is called intermolecular hydrogen bonding, and the resulting H-bonded complex can be a dimer or a polymer; tne hyorogen bonding occurring within the same molecule is called ifluia" molecular hydrogen bonding. Spectroscopic methods such as infrared, nuclear magnetic resonance, ultraviolet and Raman have been used to detect hydrogen bonding. Nonspectroscopic methods such as determination of density, dielectric constant, viscosity, etc., have also been used to detect hydrogen bonding (1). Spectroscopic methods have been used to determine the equilibrium constant mainly for intermolecular hydrogen bonding formation. Early in the development of NMR, it was recognized by a number of workers (2-1).) that the technique would be suitable for studying the above problems. A different approach by IB technique has been reported by a number of authors (5-8). Calculation of hydrogen bonding has also been made by the UV technique and reported by a number of authors (9, 10). Comparative NMR and IR discussions have been reported by Brandt and Chojnowaki (11). In the present report the RMR and IR methods were used to determine the equilibrium constant of the interaction of trichloroacetic acid and 2'-hydroxyacetophenone.

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