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dc.contributor.author Church, Allen R en
dc.date.accessioned 2017-03-20T23:39:17Z en
dc.date.available 2017-03-20T23:39:17Z en
dc.date.copyright 1969 en
dc.date.issued 1969 en
dc.identifier.other ocm57562460 en
dc.identifier.uri http://hdl.handle.net/10211.3/188648 en
dc.description.abstract A method for the synthesis of pteroyl- y-glutamyl glutamic acid (and other polyglutamates of folic acid) has been studied using folic acid as the starting material. Dimethyl folate and diethyl folate were prepared and hydrolyzed under basic conditions in dimethyl form-andde and dimethyl sulfoxide respectively. Two compounds identified as monoothyl folates were separated from hydrolysis products by paper and column chromatography. Identification of the compounds as ^ - or ^-ethyl esters could not be established. Difficulty in preparing diethyl folate in half-gram quantities prompted the investigation of dimethyl folate. Only one compound identified as monomethyl folate could be separated by paper or column chromatography. This compound was coupled with diethyl glutamate through a peptide bond by the mixed—anhydride method using isobutyl chloroiormate. ihe esterified product was hydrolyzed in .IN sodium hydroxide to the j.ree acid, fhe product, of doubtful purity, has the same Rf value by paper chromatography as that observed by other sources. The product will sustain the growth of Lactobacillus casex, although whether this is due to pteroyl- <! -glutamyl glutamic acid or folic aci d has not been determined. Tetrazolium bioautography on a paper chromatogram, which has not been successful, would establish or discount the presence of pteroyl-2f-glutarnyl glutamic acid in the product. en
dc.format.extent 43 leaves en
dc.language.iso en_US en
dc.subject.lcc fLD729.6.F74 1969.C48 en
dc.title Pteroyl-{dblunder}g-glutamyl glutamic acid: a study of a possible synthesis from folic acid en
dc.type Text en
dc.date.updated 2017-03-20T23:39:17Z en
dc.degree Master of Science (M.S.) en
dc.type.genre Theses en
dc.contributor.department California State University, Fresno. College of Science and Mathematics. Department of Chemistry en
dc.subject.category Mathematical and Physical Sciences -- Chemistry en
dc.description.illustration illustrations en
dc.description.reference Includes bibliographical references. en


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